Parkinson's disease

Parkinson's disease, or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor and non-motor systems. Symptoms typically develop gradually, with non-motor issues becoming... Wikipedia

• Symptoms:  Tremor, bradykinesia, rigidity, postural instability, dysautonomia, depression, anxiety, sleep abnormalities
• Complications:  Falls, dementia, aspiration pneumonia
• Usual onset:  Age over 60
• Duration:  Long-term
• Risk factors:  Family history, dyspepsia, general anesthesia, pesticide exposure, head injuries
• Diagnostic method:  History and neurologic examination, medical imaging, dopamine levels in urine
• Differential diagnosis:  Dementia with Lewy bodies, progressive supranuclear palsy, essential tremor, antipsychotic use, fragile X-associated tremor/ataxia syndrome, Huntington's disease, dopamine-responsive dystonia, Wilson's disease
• Treatment:  Supportive measures & control of symptoms, physical therapy, deep brain stimulation, medication
• Medication:  Levadopa, COMT inhibitors, AAAD inhibitors, dopamine agonists, MAO-B inhibitors
• Prognosis:  No known cure, near-normal life expectancy.
• Data source:  DuckDuckGo