Tuesday, Nov. 25, 2025 | 2 a.m.
If a bettor had started with a $100 wager on Michigan to beat Ohio State outright in 2021 and rolled over the winnings in each of the three successive meetings between the rivals, they’d now have roughly $28,438.
The maize and blue have owned what many call the best rivalry in college football lately, and the betting odds provide a picture of the improbability of their domination in the series. The closing moneyline prices dating back to 2021 imply less than a 0.5% chance that Michigan would win all four games, but that’s what has happened.
The only game where the market favored the Wolverines over the Buckeyes was in their 2023-2024 championship season. Michigan was only a 3-point favorite in that contest, where it held on for a 30-24 victory.
It beat Ohio State by a combined 37 points the two previous years as 8- and 7.5-point underdogs, respectively.
But the bulk of the return on the aforementioned hypothetical betting strategy — which would never be employed but works from an illustrative standpoint — came last year. Michigan went to Ohio State as closing 19-point underdog, and as high as 12-to-1 on the moneyline, before pulling off a 13-10 shocker.
This year’s rematch would be a tame upset by comparison. The defending national champion, undefeated Ohio State visits Michigan as a 10-point favorite with the odds implying about a 78% win probability.
And if the imaginary Michigan bettor wanted to risk all their $28,438 for another year? They could get a ticket to win $89,580 in Las Vegas, as the Wolverines’ best currently available moneyline price is +315 (i.e. risking $100 to win $315).
Read below to see if I give Michigan any chance by handicapping the point spread in this year’s edition of “The Game.” Picks are labeled in one of three confidence categories — plays, leans and guesses. Odds are the best available at publication time on the chosen side. The overall record so far stands at 320-292-15 (93-84-6 on plays, 109-94-4 on leans and 118-114-5 on leans)
Big Games
Ole Miss -6.5 at Mississippi State, over/under: 63.5. In this era of college football where players are on the move for better opportunities even more than coaches, are the former really distracted by the latter? They might be, but this line is pricing it as a definite that the Rebels will be weakened by coach Lane Kiffin’s wandering eyes. Don’t pay a premium to fade Ole Miss when the line would have been 10 or higher two weeks ago. Play: Ole Miss -6.5.
Georgia -12.5 at Georgia Tech, over/under: 59.5. Georgia Tech left an impression by taking Georgia to eight overtimes last year before an eventual 44-42 loss as 17-point underdogs. But Georgia was trending downwards at the end of last year. It’s the exact opposite this year, as the Bulldogs have only recently started to look like a bona fide threat to win the national championship. Guess: Georgia -12.5.
Texas A&M -2.5 at Texas, over/under: 51.5. This line was Texas -10.5 coming into the season. The teams’ seasons have diverged but arguably not quite enough to merit a 13-point move. Texas still has the better roster, and has shown signs of life recently — arguably outplaying Texas A&M over the last month. Lean: Texas +2.5.
Ohio State -10 at Michigan, over/under: 44.5. Recent series history aside, laying double digits on the road in a rivalry game against a competent opponent with a team who’s two best offensive players are hurt isn’t a winning strategy. Neither wide receiver Jeremiah Smith nor wide receiver Carnell Tate played in Ohio State’s 42-9 win over Rutgers as 31-point favorites last week, and there’s been no clarity on their status this week. Guess: Michigan +10.
Oregon -7 at Washington, over/under: 53. There might not be a more concerning injury list in the nation than the Ducks’ as they’ve now got cluster injuries both at wide receiver and offensive line. It hasn’t mattered yet but it’s bound to catch up to them at some point, perhaps on the road in an underrated rivalry game. Wait to see if Washington +7.5 appears to unload an actual play. Lean: Washington +7.
LSU +10.5 at Oklahoma, over/under: 37.5. Both these offenses barely crack the nation’s top 100 in expected points added (EPA) per play; both these defenses rate in the nation’s top 15 in EPA per play. The game is unlikely to feature enough points for either team to pull away for a double-digit victory. Lean: LSU +10.5.
Vanderbilt +2.5 at Tennessee, over/under: 64.5. Vanderbilt is a great story and merits serious College Football Playoff consideration, but its 128th in the nation in pass defense by EPA per play. It’s gotten fortunate to avoid most of the best passing offenses in the SEC, but that changes against Tennessee quarterback Joey Aguilar and Co. Guess: Tennessee -2.5.
Alabama -5.5 at Auburn, over/under: 46.5. The number is exactly right — as evidenced by minimal movement in two weeks since it’s been posted at some local sports books — but Alabama has a better X-factor in stabilizing-force Ty Simpson at quarterback. Auburn’s upside is similar to their Iron Bowl rival’s, but it’s more mistake-prone and less trustworthy. Guess: Alabama -5.5.
Big Plays
Iowa -4.5 at Nebraska, over/under: 39.5. Even now with more than a two-game sample illustrating the downgrade from injured quarterback Dylan Railoa to current fill-in TJ Lateef, the market continues to minimize the impact on the Cornhuskers. Iowa, meanwhile, is a couple plays away from the playoff conversation with losses of less than a touchdown to Indiana, Oregon and USC. Few teams are more underrated than the Hawkeyes. Play: Iowa -4.5.
Kentucky +3.5 at Louisville, over/under: 47.5. Louisville quarterback Miller Moss may play after missing last week’s dreadful 38-6 loss to SMU as 3.5-point underdogs, but he won’t be 100% healthy. Whether it’s the perpetually disappointing Miller or the green Deuce Knight, a menacing Wildcats’ defensive front should cause havoc. Play: Kentucky +3.5.
Wisconsin +1.5 at Minnesota, over/under: 37.5. Few teams in the nation have improved more than Wisconsin, which have now covered in four straight games all against teams in the upper half of the Big Ten. The Gophers have gone the other way with only one straight-up win in the span against a weaker schedule. Play: Wisconsin +1.5.
Missouri -2 at Arkansas, over/under: 58. Arkansas still profiles decently through the lens of its season-long numbers, but its efficiency on offense has taken a nosedive in recent weeks. Missouri meanwhile is still fighting and should be better with Beau Pribula having another week to recover in his second game back from what looked like a season-ending leg injury last month. Play: Missouri -2.
Northwestern +6.5 at Illinois, over/under: 47.5. The Wildcats realized their season-long mission last week by holding off Minnesota 38-35 as 4-point favorites to reach bowl eligibility. Talent-richer Illinois has more left to prove after losing three of its last five games to put a damper on what was once hailed as a potential banner season for the program. Play: Illinois -6.5.
Arizona +1.5 at Arizona State, over/under: 48.5. Nothing can speak higher of Arizona State coach Kenny Dillingham’s ability than winning three straight games with journeyman quarterback Jeff Sims at the helm. But Sims remains a liability, especially going into the Territorial Cup against a rising archrival that’s seen everything come together in a three-game winning streak. Play: Arizona +1.5.
Other Games
Play: Washington State -13.5 vs. Oregon State
Play: Texas State -9 vs. South Alabama
Play: Louisiana -10 vs. Louisiana-Monroe
Play: Iowa State -13.5 at Oklahoma State
Play: Marshall -7 vs. Georgia Southern
Play: UNLV -7.5 at UNR
Lean: USC -21 vs. UCLA
Lean: Miami -6.5 at Pittsburgh
Lean: Penn State -11 at Rutgers
Lean: Western Michigan -6.5 at Eastern Michigan
Lean: Virginia -10 vs. Virginia Tech
Lean: Duke -1 vs. Wake Forest
Lean: Memphis -5.5 vs. Navy
Lean: UTEP +5.5 at Delaware
Lean: Central Michigan +10.5 vs. Toledo
Lean: Boise State -3 at Utah State
Lean: Michigan State -4 vs. Maryland
Lean: Florida State +2.5 at Florida
Lean: Texas Tech -23.5 at West Virginia
Lean: Indiana -28 at Purdue
Lean: Northern Illinois -4.5 vs. Kent State
Lean: Miami (Ohio) -17.5 vs. Ball State
Lean: Louisiana Tech +3 at Missouri State
Lean: Troy +7 at Southern Miss
Lean: Kennesaw State -1.5 at Liberty
Lean: Hawaii -8 vs. Wyoming
Lean: East Carolina -6.5 at Florida Atlantic
Lean: Old Dominion -26.5 vs. Georgia State
Lean: UAB +9 at Tulsa
Lean: Florida International -10 at Sam Houston State
Lean: Boston College -3 at Syracuse
Lean: Colorado +17.5 at Kansas State
Guess: UCF +18.5 at BYU
Guess: South Carolina -2.5 vs. Clemson
Guess: Tulane -29.5 vs. Charlotte
Guess: New Mexico +1.5 vs. San Diego State
Guess: Massachusetts +15 vs. Bowling Green
Guess: Arkansas State +2.5 at Appalachian State
Guess: Army +8 at UTSA
Guess: Baylor -2 vs. Houston
Guess: South Florida -27.5 vs. Rice
Guess: North Texas -20 vs. Temple
Guess: Stanford +33 vs. Notre Dame
Guess: Fresno State -2.5 at San Jose State
Guess: North Carolina +8.5 at NC State
Guess: California +13.5 vs. SMU
Guess: Ohio -6.5 at Buffalo
Guess: Kansas +13.5 vs. Utah
Guess: Western Kentucky -2.5 at Jacksonville State
Guess: TCU -3.5 vs. Cincinnati
Guess: Coastal Carolina +22.5 vs. James Madison
Guess: Middle Tennessee +4.5 at New Mexico State
Guess: Colorado State +2.5 vs. Air Force
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