England wing Immanuel Feyi-Waboso will make his return against a France XV on Saturday after six months out though injury.
The 22-year-old Exeter flier dislocated his shoulder against Sale in December and suffered a setback during an international training camp before having an operation.
Bath flankers Ted Hill and Guy Pepper also start after playing key roles in last weekend's Premiership final victory over Leicester, with Saracens' Tom Willis between them at number eight.
Sale's Joe Carpenter is at full-back and Gloucester's Seb Atkinson at 12, but both will have to wait for his first cap with the match against a second-string French outfit not being classified as a Test.
Fly-half George Ford and hooker Jamie George co-captain the side while Northampton's Alex Coles, who last appeared for England during the tour of New Zealand last summer, earns a shot in the second row.
The Harlequins forward trio of Chandler Cunningham-South, Jack Kenningham and Alex Dombrandt are on the bench, alongside Sale scrum-half Raffi Quirke.
England: Carpenter; Roebuck, Slade, Atkinson, Feyi-Waboso; Ford (co-c), Spencer; Baxter, George (co-c), Heyes, Coles, Isiekwe, Hill, Pepper, Willis
Replacements: Dan, Rodd, Davison, Cunningham-South, Kenningham, Dombrandt, Quirke, Beard