College football prediction trends: Edges go to Ohio State, Tennessee

Ohio State holds an edge against Indiana, with the Buckeyes posting a 6-1 ATS record as a road team since last season, while the Hoosiers are just 1-4 ATS this season and 3-6 ATS in their last nine games in Bloomington as favorites. Florida is favored against Texas, as the Longhorns have lost their last four games against the spread this season and are 5-7-1 ATS in Austin since early last season, while Jon Sumrall’s teams are 8-3 ATS as underdogs in regular-season games dating to 2022. Tennessee gets a slight edge over Alabama, with the Volunteers having won and covered each of the past five 'Third Saturday in October' meetings, despite Alabama being 2-0 SU and ATS on SEC road games this season.

Northwestern is favored against Michigan State, having covered the spread in all five of their 2026 games and posting a 9-4-1 ATS record as a Big Ten road team under David Braun, while the Spartans are on a 2-12 straight-up slide since early last season and 1-4 SU in 2026. Arizona State holds a slight edge over Texas Tech, with the Sun Devils being 8-2 ATS in their last 10 Big 12 games away from Tempe (1-0 this season), while Texas Tech is only 1-3-1 ATS this season after an 11-2 ATS mark in 2025. The over is favored in Mississippi State vs. LSU, as the Bulldogs are on a 10-1 over run since mid-2025, and in Missouri vs. Ole Miss, where the Rebels are on a 6-1 over run since late last season.

Sources: Las Vegas Review-Journal